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These studies generally demonstrate favorable safety profiles, although their therapeutic efficacy is often limited by poor aqueous solubility, rapid metabolism, and low systemic bioavailability
3.3 Oxidative stress impairs reproductive function Mitochondrial dysfunction and excessive ROS production are characteristics of ferroptosis, and mitochondrial dysfunction further promotes ROS production, leading to oxidative stress, which induces the development and exacerbation of ferroptosis (112, 113)
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Human bone marrow mesenchymal stem cell behaviors on PCL/gelatin nanofibrous scaffolds modified with a collagen IV-derived RGD-containing peptide