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Therefore, M3-type cholinergic receptors and GRP receptors are also involved in metformin-induced changes in GLP-1 secretion

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The most common ones are gastrointestinal, such as nausea, vomiting, diarrhea, and constipation, especially when starting treatment or increasing the dose

Cost alone does not determine treatment successbiomarkers, genetic predispositions, and individual metabolic response patterns significantly influence which medication and dosage strategy may be appropriate for each patient

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