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However, dysregulation of necroptosis has been shown to be associated with several diseases and tissue damages including cancer (Dhuriya and Sharma, 2018), ischemia/reperfusion injury (Fulda, 2013), acute pancreatitis (Wang G

Heat shock proteins (HSPs), oxidative stress response genes including SOD1 and GPX1, and DNA repair pathways show activation patterns that correlate with embryo resilience and developmental success [402, 403]

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For hair-specific applications, some protocols combine systemic subcutaneous GHK-Cu with direct scalp delivery via mesotherapy, injecting diluted GHK-Cu solution directly into the scalp to maximize follicle-level exposure alongside systemic administration

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