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Obes Rev (2022) 23:e13372

Nakagawa, T

American journal of physiology Heart and circulatory physiology

Once-weekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): a randomised, open-label, phase 3, non-inferiority study

24.2% average weight loss over 48 weeks

Retatrutide is promising because of its triple-agonist mechanism and strong weight-loss data, but current public evidence is not enough to make a firm superiority claim specifically for muscle preservation compared with semaglutide or tirzepatide