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[DOI] [PubMed] [Google Scholar] 171.Dimri U., Ranjan R., Kumar N., Sharma M.C., Swarup D., Sharma B., Kataria M

Based on promising preclinical data, a dual GIP/GLP-1 receptor agonist, named twincretin, has been developed and emerging evidence showed that in Phase 3 clinical trials, tirzepatide was able to induce a potent glucose-lowering and weight loss with adverse effects comparable to those of established GLP-1 receptor agonist

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First, scopolamine-induced cognitive impairment in young rats used in McCoy 2013 and Benoist 2014 as a pharmacological model of cholinergic disruption of spatial learning, with Morris water maze as the primary behavioral readout