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It operates under a principle of strict liability

Bioorganic & Medicinal Chemistry, 26(10), 2700-2707

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Chronic neuroinflammation causes neuronal damage, which results in long-term impairment

By selectively inhibiting NNMT , 5-Amino-1MQ can reduce the methylation of nicotinamide, leading to increased intracellular NAD availability and enhanced metabolic activity

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