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Preliminary findings suggest that these drugs may have even more unexpected off-label uses, such as helping to reduce alcohol use disorder (AUD) , reduce high blood pressure (hypertension) , and provide defense against heart disease and even dementia

The search strategy combines Medical Subject Headings (MeSH) and keywords including GLP-1, glucagon-like peptide-1 receptor, GLP-1 receptor agonist, sepsis, systemic inflammation, infection, immune response, critical illness, MODS, multiple organ dysfunction, cytokines and sepsis treatment. Articles were screened for relevance based on titles and abstracts, with full-text evaluation of studies addressing the mechanistic or therapeutic implications of GLP-1 signaling in experimental or clinical models of sepsis

Diabetes Obes Metab (2020) 23(4):10526

Dosing accuracy concerns Smaller individual doses are harder to measure accurately