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When the prostate gland becomes enlarged, it can cause problems with urination
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In preclinical studies conducted at Cornell University in laboratory cats, no adverse effects or unanticipated events were observed
When intra-portal insulin levels are increased (e.g., obesity, Cushings syndrome, or due to treatment with glucocorticoids and glucagon-like peptide 1 receptor agonists) or decreased (e.g., malnutrition, anorexia nervosa and type 1 diabetes mellitus), these changes secondarily alter hepatic GH sensitivity resulting in a secondary association with discordant GH and IGF-I levels (e.g., high GH/low IGF-I levels or low GH/high IGF-I levels, respectively)
This expedited review reflects the FDA's recognition of the significant unmet medical need in obesity treatment and the potential for orforglipron to expand access to GLP-1 therapy
