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The interest and use of nutraceuticals that can play a supportive role in health and skin aging has increased dramatically in the last 10 years, with products containing vitamin C and E, collagen, omega-3 fatty acids, and antioxidants such as curcumin, glutathione, and resveratrol, which have multiple anti-inflammatory, protective effects against oxidative stress and age-related decline in cellular function [79,80,81]

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Native polyphenols, such as flavonoids, ellagitannins, phenolic acids, and lignans, are poorly absorbed in their original form and undergo substantial microbial biotransformation in the colon [149, 150]

Enhanced resistance to viruses in nicotiana edwardsonii ColumbiaIs dependent on salicylic acid, correlates with high glutathione levels, and extends to plant-pathogenic bacteria and abiotic stress

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