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The Pro-Gly-Pro tail was added to slow enzymatic breakdown so the molecule has a longer functional window than the bare ACTH fragment

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As coactivators that connect acetylated transcription factors and histones to the activation of RNA polymerase II, the bromodomain and extra-terminal domain (BET) family proteins preferentially promotes the transcription of oncogenes such as Myc, HER3, MET, and IGF-IR [136,137,138]