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Neal EG, Zupec-Kania B, et al
The half-life of injectable tirzepatide is approximately 5 days
The authors found that DRD2 was predominantly intracellular in M 2 cells, a human melanoma cell line does not express FLNA, whereas it localized at the plasma membrane in A 7 cells, the same line stably transfected with FLNA, suggesting that FLNA is required for the cell surface localization of DRD2, as also demonstrated by using a dominant negative truncated form of FLNA (repeats 1819, containing the DRD2, but not the actin, binding domain) (80)
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