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Wei Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Pregnant or nursing women, children under 18 and individuals with known medical condition should consult their physician prior to taking

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Persistent symptoms may indicate thyroid changes, medication dose adjustment needs, or unrelated medical conditions requiring evaluation

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(11) These comparative studies have revealed how binding proteins regulate IGF-1 bioavailability and how the removal of IGFBP binding capacity affects biological responses