GLP-1 medications work partly by suppressing appetite and slowing gastric emptying. That's the mechanism behind the weight loss. But less food in means fewer vitamins and minerals in and the research now shows this isn't a theoretical concern. Butsch et al. (2025), the largest of the six studies in the Urbina review, tracked 461,382 GLP-1 users and found 22.4% had a new nutritional deficiency diagnosis within 12 months. Vitamin D was most common (13.6%), followed by nutritional anemia (4%), iron deficiency (3.2%), and B vitamin deficiency (2.6%). In a smaller dietary study (Johnson et al. 2025, Frontiers in Nutrition), 64% of GLP-1 users didn't meet iron intake recommendations, and 72% fell short on calcium.* This GLP-1 supplement covers the five most at-risk nutrients with bioavailable forms: methylcobalamin B12, chelated iron, chelated zinc, 5-MTHF folate, and vitamin D3
If you feel sluggish regularly (or have a chronic illness), you may be depleted in B vitamins
Given the array of symptoms a vitamin B 12 deficiency can cause, the condition can be overlooked or confused with something else
RGD-GHK significantly promoted the mRNA level of loricrin (LOR) and filaggrin (FLG), which were associated with a marked reduction in the damaged skin barrier
Growth hormone peptides Growth hormone plays important roles in healing and recovery
10.1523/JNEUROSCI.3262-11.2011 12 DoutonJ
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