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Abstract Chronic kidney disease (CKD) is a progressive condition characterized by the gradual loss of kidney function, leading to the accumulation of uremic toxins in the bloodstream

Our lab has tested these extensively, and our findings are quite clear

10.1093/oxfordjournals.jbchem.a126647 449 OldfieldC

This is more likely when B12 is given in injectable form rather than taken orally

However, severe cervical spinal cord compression (cervical myelopathy) can potentially affect leg function, though this represents a different and more serious condition

This is due to the inhibition of DNA synthesis (specifically purines and thymidine)