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Moreover, increased cellular uptake of Zn 2+ through the upregulation of zinc transporter ZIP8 activates metal-regulatory transcription factor-1 (MTF1), which in turn induces the expression of matrix-degrading enzymes in chondrocytes 33,83

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16 patients with distinct BCC subtypes were prospectively assessed and treated with IM gel 0.05% once daily for two days in a row under occlusion