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Novo Nordisk, Eli Lilly, and others are now in full swing, taking all these initial observations and putting them through the various trial phases

Comparison of GI AEs Across GLP-1 RAs GI AEs are the most frequently reported classwide effects of GLP-1 RAs

However, professional guidance places emphasis on establishing a genuine clinician-patient relationship rather than relying on questionnaire-only prescribing

Real-world outcomes: According to a 72-week phase 3b trial, adults with obesity (but without diabetes) treated with tirzepatide were significantly more likely to lose at least 10% or 15% of their body weight than those treated with semaglutide

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Patients enquiring about GLP-1 agonists for alcohol problems should be directed to evidence-based treatments currently available through NHS addiction services, including community alcohol teams, specialist clinics, and psychological interventions such as cognitive behavioural therapy and motivational enhancement therapy