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Holt MK, Trapp S

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Semaglutide: about 14.9% The landmark STEP 1 trial published in the New England Journal of Medicine reported average weight loss of 14.9% at 68 weeks with once-weekly semaglutide 2.4 mg in adults with overweight or obesity, compared with 2.4% for placebo

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In human islets, GLP-1 promotes increased connectivity between individual cells to improve calcium kinetics and insulin secretion throughout the islets, and promotes insulin secretion from islet cells when cells detect both elevated blood glucose levels and hormonal signals from the intestine

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doi: 10.1097/DAD.0000000000000036

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Both achieve the same clinical outcomes

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A WFPB diet is rich in anti-inflammatory compounds found in fruits, vegetables, nuts, seeds, and whole grains

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