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According to the MHRA-approved product information, these include: Nausea (very common, affecting more than 1 in 10 patients) Vomiting and diarrhoea (common, affecting up to 1 in 10 patients) Abdominal pain and constipation (common) Decreased appetite (common) These gastrointestinal symptoms typically occur during the initial weeks of treatment or following dose escalation and often diminish over time as the body adjusts to the medication

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d , BN-PAGE immunoblot on isolated WAT mitochondria from Control mice at ZT2 and ZT14 using an antibody mix against OXPHOS complex subunits (n = 5)

For patients with metabolic disorders, L-Carnitine supplementation can be critical