During the oxidation step, the standard iodine solution was replaced with phenylacetyl disulfide solution (5 g in 2 ml pyridine) to achieve PS modification
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PBN was also shown to interfere with genes encoding inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory cytokines (Maples et al., 2004
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Combined as synbiotics, prebiotics, and probiotics show promise in treating IBS by modulating microbiota, gut barrier function, immune responses, and the gut-brain axis (216)
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