The compound is a potent dual agonist on hMC3R (EC 50 = 0.073 nM, E max = 96%) and hMC4R (EC 50 = 0.042 nM, E max = 101%) ( This novel approach to melanocortin receptor selectivity for weight loss was informed by our previous work demonstrating that co-administration of an MC4R-selective agonist and an MC3R-selective agonist caused a greater reduction in food intake and body weight in DIO NHPs than administration of either compound alone, yielding 7.8% weight loss after 36 days ( The role of dual agonism is further emphasized by 710GO, which displays agonist activity on both MC3R and MC4R
How fast is too fast
Intakes below 800 calories per day constitute very low calorie diets (VLCDs) and should only be followed under medical supervision
Based on our research, WeightWatchers Clinic users are highly satisfied with the program and get great results from using GLP-1 medication in conjunction with WeightWatchers Points to track their food intake
I think that what we're finding is that patients who have experienced weight loss, whether or not it's on a GLP-1 medication, are seeing just a global health improvement, Levites said
Cost per effective dose is broadly comparable and depends on supplier and protocol
