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Some individuals living in these highlands for extended periods are unable to adapt to the low-oxygen and low-pressure environment

Plain Language Summary Type 2 diabetes mellitus is a disease which, over time, can cause higher than normal levels of sugar in the blood (hyperglycemia) which can be harmful if not treated

This is not recommended as standard treatment, because of potential negative effect of physostigmine on cardiac conductance

Semaglutide amplifies the action of GLP-1, suppressing hunger signals and encouraging the body to prioritize fat utilization for energy

Semaglutide is an FDA-approved GLP-1 receptor agonist administered as a weekly injection