Introduction The discovery and development of tirzepatide represent a milestone in modern drug therapy for the treatment of type 2 diabetes mellitus and obesity, as it combines in a single molecule the agonist action of glucose-dependent insulinotropicpeptide(GIP)andglucagon-likepeptide-1(GLP-1) receptors
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Koeth RA, Wang Z, Levison BS, Buffa JA, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL: Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
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