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One consideration is the distribution of GLP-1 receptors throughout the central nervous system

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At low and microdoses, they help regulate the same key hormones with fewer side effects

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The aim of this review was to summarize the recent updates from both clinical trials and preclinical experiments on the impact of GLP-1 receptor agonists (GLP-1RAs) and DPP-4 inhibitors (DPP-4i) on cardiovascular outcomes