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Determination of glutathione and glutathione disulfide in biological samples: an in-depth review
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Nat Rev Clin Oncol 18(5):280296 Jakaria M, Belaidi AA, Bush AI, Ayton S (2021) Ferroptosis as a mechanism of neurodegeneration in Alzheimers disease
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Its hexameric ring structure exhibits a sophisticated mechanical working mechanism: the N-terminus recognizes and binds the substrate, and the AAA+ domain drives substrate unfolding through ATP hydrolysis, delivering the unfolded polypeptide chain to the C-terminal serine protease active center for degradation [9,10,11]
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