Eating behavior has been hypothesized to influence therapeutic efficacy, but supporting evidence remains limited
This study showed that chronic peripheral administration of liraglutide to Phox2b-Cre Glp1r flox/flox mice fed a HFD reduced food intake, body weight, and adiposity suggesting that the PNS is not required for liraglutide to mediate its effects on energy metabolism
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Moreover, recent data suggest that oxidative injury may play a significant role in demyelination and pathogenesis in MS [116]
Due to the small number of subjects having hyperlipidemia in the LC group, the detection of the lipid-lowering effects in these subjects may have been limited
This move is in an attempt to prevent cachexia, which accounts for 20% of cancer mortalities (5)