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What we dont yet know Long-term cardiovascular outcomes

Reduces Cell Damage In Hepatic Disease Hepatitis, Non-alcoholic fatty liver disease, and alcohol consumption like conditions damage the liver cells

It is also listed on the PBS for patients who fulfill the following key clinical criteria: an eGFR of 25 mL/min/1.73 m 2 or greater an ACR of 22.6 mg/mmol or greater must be on a stable dose of either an ACE inhibitor or ARB must not have established heart failure with reduced ejection fraction must be on an SGLT-2 inhibitor unless medically contraindicated or intolerant (please refer to the full PBS clinical criteria at: Combination therapy Some evidence suggests that combination therapy with SGLT-2 inhibitors and mineralocorticoid receptor antagonists in patients with type 2 diabetes and CKD reduces the risk of CV events and the mineralocorticoid receptor antagonist-associated risk of hyperkalaemia without a significant interaction between the two drugs

Understand what you're getting before deciding which route makes sense for your situation

While SGLT2 inhibitors are clinically very important for heart and kidney health, the dramatic weight loss results of GLP-1s have made them a much bigger topic of conversation

They treat obesity as a chronic metabolic disease instead of expecting people to rely solely on willpower and lifestyle changes to manage their condition