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Protein aggregation-driven UPS impairment in sporadic NDDs In addition to genetic mutations, UPS dysfunction is also a defining feature of sporadic NDDs, where aggregation-prone proteins directly impair proteasomal function
3 Further weakening of immune resistance against FIP
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40hr BSO: Cells treated with BSO, washed at 20 hours and fresh media plus BSO added
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Despite exhibiting an intracellular lifestyle within IECs, it was recently discovered that the foodborne pathogen, Listeria monocytogenes , also employs mechanisms to aid its paracellular transport across the intestinal epithelium potentially contributing to systemic infection (Drolia et al
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