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Concerning the inhibition of NF-kB activation, it occurs through the inhibition of degradation of its cytosolic dock IkB (inhibitor of NF-kB)

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These psychomotor effects of cannabis are mainly attributed to the 9 -tetrahydrocan-nabinol ( 9 -THC), the major psychoactive constituent in Cannabis sativa plant by acting on the cannabinoid (CB1) receptor that is highly expressed in the basal ganglia, the cerebral cortex and the cerebellum (Ameri, 1999

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In addition, NADPH was decreased in the kidneys with TLS, which is consumed in the reduction of cystine to cysteine and GSSG to GSH