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thermophilus ) are observed to induce mucosal IgA production by SCFAs such as butyrate, which inhibit HDACs to epigenetically activate TGF-/Smad3 signaling in DCs, resulting in class-switching of B cells to IgA+ plasma cells in the gut mucosal lining in a dose-dependent manner (143, 144)

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J Nat Med 60(4):303307 Jiang Z, Jin M, Zhou W, Li R, Zhao Y, Jin X, Li G (2018) Anti-inflammatory activity of chemical constituents isolated from the willow bracket medicinal mushroom Phellinus igniarius (Agaricomycetes)