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114,132 Sirtuins have been considered major targets of NAD regulation of aging and longevity

Papadopoulou, C., Reinhold, J., Grner-Hegge, N., Kydd, A., Bhagra, S., Parameshwar, K

This fundamental difference in duration reflects their distinct safety and efficacy profiles

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Comparing the results of phase 2 clinical trials of these two drugs (baseline characteristics of populations were similar), 51,52 tirzepatide seemed to be more efficacious in improving T2DM