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The tumor suppressor protein p53 increases the expression of the aspartate/glutamate transporter SLC1A3 and the arginine transporter SLC7A3 upon glutamine depletion, leading to resistance to treatments that deplete extracellular glutamine 114,115

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To help your body adjust safely and comfortably, your doctor will start you on the lowest possible initiation dose, which is typically 0.25 mg