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Methods Data Source and Study Design This study is a post hoc secondary analysis of data from the randomized, double-blind, event-driven SELECT trial (NCT03574597) of once-weekly subcutaneous administration of semaglutide compared with placebo in 17,604 patients with established CVD and obesity

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Fatigue emerged as the second most frequently reported complaint despite limited representation in RCT datasets which may reflect differences between structured trial environments and real-world use