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doi: 10.3390/jcm12237502

Molina-Sotomayor et al., 2020) and BDNF (Berbert-Gomes et al., 2024

Additionally, paeoniflorin was reported to reduce the expression of the L-tryptophan-catabolizing enzyme tryptophan-2,3-dioxygenase in the liver of stress-induced depressive mice, thereby increasing the 5-hydroxytryptamine/tryptophan ratio and decreasing the kynurenine/tryptophan ratio (Liang et al., 2023)

(To confirm candidate suitability)

Because its primary mechanisms involve circulating through the bloodstream and signaling cells throughout the body supporting collagen production in the skin, hair follicle health on the scalp, and tissue remodeling in joints and connective tissue all at once a delivery method that reaches systemic circulation efficiently is arguably better matched to how GHK-Cu actually works than a localized injection