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Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, Khachaturian AS, Vergallo A, Cavedo E, Snyder PJ, Khachaturian ZS (2018) The cholinergic system in the pathophysiology and treatment of Alzheimers disease

7 Discussion GLP-1 RAs have shown effects beyond their initial application in managing T2DM

1E), however, in the early DM group, food intake was lower in the semaglutide group and the tirzepatide group compared to the control group (Fig

Several studies have shown that complete withdrawal of an obesity treatment dose of a GLP-1RA without other structured care leads to weight regain in most people.2 However, it remains unclear whether lifelong treatment of obesity should always consist of GLP-1RAs at full obesity dosing or whether a range of alternative strategies can enable some subset of people with obesity to maintain their weight loss after a limited duration of initial treatment, followed by tapering, discontinuing, or off-ramping these agents." This paragraph from the article, I believe, sums up nicely what this means

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Developmental delay, mental retardation, autism spectrum disorder, acquired microcephaly, and psychiatric abnormalities are also commonly observed in most patients [4, 6, 9, 10]