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Furthermore, in vivo administration of compound 17 significantly reduced the severity of LPS-induced sepsis in C57BL/6J mice, resulting in less damage to various organs

Importantly, degradation kinetics can be precisely controlled to match the therapeutic timelinefor instance, maintaining mechanical separation of organs during the full course of brachytherapy, while simultaneously providing sustained local delivery of radiosensitizers, chemotherapeutics, or immunomodulators [136]

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Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion