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Trials like IRMA-2 (Parving et al, NEJM 2001) demonstrate a reduced risk of progression of CKD in patients with diabetes and moderately increased albuminuria (30-300mg/day) using RAS blockade

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Koch, J

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These include orlistat, liraglutide, and semaglutide (NICE TA875 for weight management in adults with obesity), as well as GLP-1 receptor agonists within the framework of NICE NG28 (type 2 diabetes management)

It has a stronger effect than Ipamorelin