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Morning or evening does not appear to matter significantly, though consistency in timing helps establish a routine

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Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled study

Median complete local pain response rates ranged from 80% to 100%, with median local pain-free survival rates reaching 76.8% (IQR 55.383.8) at the longest follow-up