However, unlike their well-characterised role in transcription, the mechanisms by which TFs influence splicing are elusive
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Sickle RBCs have a decreased NAD redox potential, demonstrated by a reduced ratio of NADH to total NAD (NAD + plus NADH) when compared to normal RBCs
First, etomoxir, a potent irreversible inhibitor of CPT1, was used in this experiment, and some research data have shown that it can inhibit lipid oxidation by targeting CPT1 [32]
Subsequently, we applied a focused refinement approach on the particles used in the reconstruction of holo-complex to improve the resolution for c-MET I and HGF I, resulting in a new cryo-EM map with resolution improved to 4.5 , which allowed us to build reliable models for the K3 and K4 domains of HGF (Supplementary Figs
10.1074/jbc.275.18.13727 [DOI] [PubMed] [Google Scholar] Petaja-Repo U