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To balance the redox state and intracellular iron homeostasis, excess intracellular Fe 2+ can be translocated out of the cell via the carrier SLC40A1 (73, 74)

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Then, it upregulated the expression of PINK1, Parkin, Beclin-1, and LC3-II/I, downregulated sterol regulatory element binding transcription factor 1 (SREBP1), liver X receptors (LXR), and stearoyl-CoA desaturease1 (SCD1) expression, enhanced mitophagy, and attenuated hepatocyte steatosis

After one week without adverse effects, many progress to 0.5 mg daily

Carasi, P., Racedo, S

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