Compared to 108 control subjects without evidence of dementia, subjects with dementia of Alzheimer's type and confirmed Alzheimer's disease had higher blood levels of homocysteine and lower blood levels of folate and vitamin B 12
In the context of gut health research, it is studied for its influence on gut-associated lymphoid tissue, barrier permeability regulation, and interaction with the gut microbiome-immune axis
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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver
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