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The conversation covers how our understanding of obesity as a chronic, relapsing disease has changed over the past 30 years, what the new clinical versus preclinical obesity framework means for how we diagnose and treat it, how GLP-1 drugs work and why they've succeeded where earlier medications failed, what the STEP and SELECT trials revealed about the disease-modifying potential of semaglutide, and how patients and clinicians should be thinking about who these drugs are really for

b , Pharmacological characterization of GLP-1R wild-type and StaR

Collectively, this indicates that males may be more vulnerable to the detrimental effects of high-fat or WD in middle age, especially on amygdala-dependent associative conditioning