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If GI symptoms are severe, the solution is slower dose titration (extending intervals between increases from 4 weeks to 68 weeks), eating smaller meals with lower fat content, and potentially adding ginger or vitamin B6 which have anti-nausea effects through different mechanisms

In rare cases, diarrhoea can be severe or urgent, which may increase the risk of accidents if symptoms are ignored or unmanaged

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Fast-Absorbing Nasal Delivery Absorbed through the nasal mucosa, offering a convenient and potentially quicker onset compared to some oral options

Recent literature is cited on patients undergoing upper endoscopy with no predictability regarding holding the drug and finding retained gastric contents