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Individuals with pre-existing liver disease, hepatitis B or C, acetaminophen-induced liver injury history, or conditions causing glutathione depletion face substantially elevated overdose risk at standard doses

Overusing injections or receiving them too frequently without medical supervision may not provide additional benefits and could increase the risk of side effects

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Statistically significant level was defined as P -value 0.05)

But, there is not enough understanding about the complete effect of extended and repeated use for many years