It targets GLP-1 and GIP, the same two hormones targeted by Lillys blockbuster drugs Mounjaro and Zepbound
Frederiksen TM, Snderby P, Ryberg LA, et al
Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (surpass-3): A randomised, open-label, parallel-group, phase 3 trial
This combination may: Reduce appetite Improve insulin sensitivity Increase calorie burning Promote significant fat reduction That triple-action mechanism is what makes it different from current GLP-1 medications
An added benefit of the inulin supplement was a greater reduction in intrahepatocellular and intramyocellular lipid in the soleus muscle even after accounting for weight lost
Dysesthesia means unusual skin sensitivity, tingling, or tenderness to touch