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In some instances, local administration to the ear provides a higher therapeutic index for an active agent that otherwise have dose-limiting systemic toxicity

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Bypasses upstream endocrine stimulation: Unlike peptides that stimulate growth hormone release, IGF-1 LR3 does not depend on pituitary activation

There was a one-week interval between each testing condition (drug or vehicle) to allow for any potential carryover effects and maintain experimental integrity

Furthermore, the interaction of lectin and immune cells might trigger cytokine production

Berk M, Dean OM, Cotton SM, Jeavons S, Tanious M, Kohlmann K, et al