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Therefore, both T2DM and PD show strong connections between mitochondrial damage and increased oxidative stress, resulting in altered insulin secretion in the former case, and in neuronal damage and neuroinflammation in the latter

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While clinical trials show an average weight loss of 10.2%, in reality, some people lose over 25% of their body weight, while 32.2% lose less than 5% or even gain weight

As expected, our data suggested that increased GPX3 exerted antagonistic effects on autophagy by down-regulating AMPK phosphorylation and up-regulating mTOR