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The pyruvate generated is transported into the mitochondria to enter the TCA cycle to generate citrate

Peptides can aggregate at high concentrations, improper buffer conditions, or due to an imbalance of hydrophobic and hydrophilic properties

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Direct renal protection is achieved through decreased inflammation, fibrosis, and albuminuria, while renal protection is achieved through improved glycemic homeostasis, blood pressure, and body weight [90]

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