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Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-\(\kappa\)B activation and sensitizes toward TNF\(\alpha\)-induced cytotoxicity

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Studies have suggested that increased susceptibility to KBD in selenium-deficient populations might result from a reduced antioxidant protection associated with polymorphisms in GPX genes (60, 61), but polymorphisms in other genes have also been implicated (62)

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