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This is also supported by previous studies, whereby Gly2Ala in exendin-4 was tolerated, but the converse for GLP-1 (Ala2Gly) reduced affinity 31,32,33

The Lancet (2025): Once-weekly semaglutide 72 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial.EMC (2026): Wegovy 7.2 mg Solution for injection in pre-filled pen Patient Information Leaflet

Chondrogenic inductivity of the NPs To evaluate the in vitro chondrogenesis induced by NPs, ATDC5 cells were cultured with chondrogenic medium (MUXMX-90,041, Cyagen Bioscience, USA) containing CuS NPs or B2M-CuS NPs (50 g mL 1 )

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