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But metformin and sulfonylureas type antidiabetic drugs are compromised with several unwanted side effects such as diarrhea and lactic acidosis (demonstrated by metformin) and hepatic failure, weight gain, tachycardia and hypothyroidism (demonstrated by sulfonylureas) (7)

Double-blind, placebo-controlled pilot trial of L-Leucine-enriched amino-acid mixtures on body composition and physical performance in men and women aged 6575 years

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The researchers found that the absolute amount of muscle tissue disruption in the LCLT-supplemented group was restricted to only 41% to 45% of the damage seen in the placebo group